Pulmonary hypertension in a patient with kyphoscoliotic heart disease
https://doi.org/10.29001/2073-8552-2019-34-3-172-178
Abstract
Kyphoscoliosis is a combined spinal deformation, which leads to a decrease in the volume of ‘working’ lung tissue with the development of alveolar hypoventilation and hypoxic vasoconstriction of the pulmonary arteries. These changes in a small percentage of cases lead to increases in pulmonary artery pressure and pulmonary vascular resistance. The pathogenesis of pulmonary hypertension in kyphoscoliosis shows resemblance to pulmonary hypertension in the setting of obstructive sleep apnea or hypoventilation in the presence of obesity. Patients with already present pulmonary hypertension may theoretically be candidates for standard pathogenetic therapy, but there is currently no evidence of the effectiveness of this treatment.
About the Authors
M. B. Karabasheva
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Postgraduate Student, Hypertension Department,
15a, 3rd Cherepkovskaya str., Moscow, 121552
N. M. Danilov
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Cand. Sci. (Med.), Leading Researcher, Hypertension Department,
15a, 3rd Cherepkovskaya str., Moscow, 121552
O. V. Sagaydak
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Cand. Sci. (Med.), Researcher, Hypertension Department,
15a, 3rd Cherepkovskaya str., Moscow, 121552
D. I. Darensky
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Cand. Sci. (Med.), Cardiologist,
15a, 3rd Cherepkovskaya str., Moscow, 121552
V. K. Lazutkina
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Cand. Sci. (Med.), Radiologist,
15a, 3rd Cherepkovskaya str., Moscow, 121552
I. E. Chazova
National Medical Research Center of Cardiology
Russian Federation
Russian Federation
M.D., Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Chief of the Hypertension Department,
15a, 3rd Cherepkovskaya str., Moscow, 121552
References
1. Galiè N., Humbert M., Vachiery J.L., Gibbs S., Lang I., Torbicki A. et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the joint task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur. Heart J. 2016;37(1):67–119. DOI: 10.1093/eurheartj/ehv317.
2. Bergofsky E.H., Turino G.M., Fishman A.P. Cardiorespiratory failure in kyphoscoliosis. Medicine. 1959;38:263–318.
3. Berger R.M., Beghetti M., Humpl T., Raskob G.E., Ivy D.D., Jing Z.C. et al. Clinical features of pediatric pulmonary hypertension: A registry study. Lancet. 2012;379:537–546. DOI: 10.1016/S0140-6736(11)61621-8.
4. Hurdman J., Condliffe R., Elliot C.A., Davies C., Hill C., Wild J.M. et al. ASPIRE registry: Assessing the spectrum of pulmonary hypertension indented at a REferral centre. Eur. Respir. J. 2012;39:945–955. DOI: 10.1183/09031936.00078411.
5. Chaouat A., Weitzenblum E., Krieger J., Oswald M., Kessler R. Pulmonary hemodynamics in the obstructive sleep apnea syndrome: Results in 220 consecutive patients. Chest. 1996;109:380–386. DOI: 10.1378/chest.109.2.380.
6. Turino G.M., Goldring R.M., Fishman A.P. Cor pulmonale in musculoskeletal abnormalities of the thorax. Bull. NY Acad. Med. 1965;41:959–980.
7. Sawicka E.H., Branthwaite M.A. Respiration during sleep in kyphoscoliosis. Thorax. 1987;42:801–808. DOI: 10.1136/thx.42.10.801.
8. Smith I.E., Laroche C.M., Jamieson S.A., Shneerson J.M. Kyphosis secondary to tuberculosis osteomyelitis as a cause of ventilatory failure: Clinical features, mechanisms and management. Chest. 1996;110:1105–1110.
9. Nauffal D., Domènech R., Martínez García M.A., Compte L., Macián V., Perpiñá M. Noninvasive positive pressure home ventilation in restrictive disorders: Outcome and impact on health-related quality of life. Respir. Med. 2002;96:777–783.
Review
For citations:
Karabasheva M.B., Danilov N.M., Sagaydak O.V., Darensky D.I., Lazutkina V.K., Chazova I.E. Pulmonary hypertension in a patient with kyphoscoliotic heart disease. Siberian Journal of Clinical and Experimental Medicine. 2019;34(3):172-178. (In Russ.) https://doi.org/10.29001/2073-8552-2019-34-3-172-178
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