C-reactive protein as the unfavorable prognostic factor in patients with multifocal atherosclerosis after carotid endarterectomy
https://doi.org/10.29001/2073-8552-2014-29-2-34-39
Abstract
A total of 54 patients who underwent reconstructive surgery on carotid arteries were examined in the study. One year after surgery, all patients were divided into two groups depending on their long-term outcomes: group 1 included patients with unfavorable prognosis (n=34; 62.9%); group 2 consisted of patients with favorable prognosis (n=20; 37.1%). In preoperative period, all patients were tested for serum levels of C-reactive protein. The study showed that patients who developed cardiovascular events such as stroke, transient ischemic attack, myocardial infarction, death, and aggravation or the first presentation of the clinical signs of ischemia in any vascular region during the first year after the surgery had significantly higher preoperative levels of C-reactive protein in serum.
About the Authors
A. V. Frolov
Research Institute for Complex Issues of Cardiovascular Diseases of Siberian Branch under the Russian Academy of Medical Sciences; Kemerovo State Medical Academy
Russian Federation
Russian Federation
O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases of Siberian Branch under the Russian Academy of Medical Sciences; Kemerovo State Medical Academy
Russian Federation
Russian Federation
References
1. Palmerini T., Marzocchi A., Marrozzini C. et al. Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis // Eur. J. Cardiothorac. Surg. - 2007. -Vol. 31. - P. 685-690.
2. Гавриленко А.В., Воронов Д.А., Кочетов С.В. Прогнозирование результатов реконструкций и вероятности прогрессирования атеросклероза на основании уровня плазменных цитокинов // Ангиология и сосудистая хирургия. - 2010. -Т. 16, № 3. - С. 146-151.
3. Grad E., Danenberg H.D. C-reactive protein and atherothrombosis: Cause or effect? // Blood Reviews. - 2013. -Vol. 27. - P. 23-29.
4. Silva D., A. Pais de Lacerda. High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease // Cardiologia. - 2012. - Vol. 31, No. 11. - P. 733-745.
5. Perry T.E., Muehlschlegel J.D., Kuang-Yu Liu et al. Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting // Anesthesiology. - 2010. - Vol. 112, No. 3. - P. 607-613.
6. Algarra M., Gomes D., Joaquim C.G. et al. Current analytical strategies for C-reactive protein quantification in blood // Clinica Chimica Acta. - 2012. - Vol. 415. - P. 1-9.
7. Пивень А.В., Гавриленко А.В., Иванов В.А. и др. Сравнительные исследования каротидной эндартерэктомии и каротидного стентирования у пациентов со стенозами сонных артерий (часть II) // Ангиология и сосудистая хирургия. - 2010. - № 2. - С. 141-147.
8. Wu S.L., J.F. Li, Li Y. et al. The distribution and influential factors of serum high sensitivity C-reactive protein in general population // Zhonghua Nei Ke Za Zhi. - 2010. - Vol. 49. -P. 1010-1014.
9. Amer M.S., Elawam A.E., Khater M.S. et al. Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults // J. Am. Soc. Hypertens. - 2011. - Vol. 5, No. 5. - P. 395-400.
10. Thejaswini K.O., Roopakala M.S., Dayananda G. et al. А study of association of ankle brachial index (ABI) and the highly sensitive C-reactive protein (hsCRP) in type 2 diabetic patients and in normal subjects // J. Clin. Diagnostic Res. - 2013. - Vol. 7, No. 1. - P. 46-50.
11. Рагино Ю.И., Чернявский А.М., Волков А.М. и др. Факторы и механизмы развития коронарного атеросклероза. - Новосибирск: Наука, 2011. - 168 с.
12. Albuquerque L.C., Narvaes L.B., Maciel A.A. et al. Intraplaque hemorrhage assessed by high-resolution magnetic resonance imaging and C-reactive protein in carotid atherosclerosis // J. Vasc. Surg. - 2007. - Vol. 46, No. 6. - P. 1130-1137.
13. Bonati L.H., Ederle J., Dobson J. et al. Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy // Int. J. Stroke. - 2013. - P. 1-9.
Review
For citations:
Frolov A.V., Barbarash O.L. C-reactive protein as the unfavorable prognostic factor in patients with multifocal atherosclerosis after carotid endarterectomy. Siberian Journal of Clinical and Experimental Medicine. 2014;29(2):34-39. (In Russ.) https://doi.org/10.29001/2073-8552-2014-29-2-34-39
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