ВОССТАНОВЛЕНИЕ ФУНКЦИИ КОНДУИТА РАДИАЛЬНОЙ АРТЕРИИ ДЛЯ ШУНТИРОВАНИЯ КОРОНАРНОЙ АРТЕРИИ

Авторы изучили влияние лерканидипина на функциональное состояние лучевой артерии, используемой в качестве шунта для аортокоронарного шунтирования у пациентов со стенозом коронарной артерии. Эндотелийзависимую вазодилатацию (ΔD) оценивали до операции с использованием ультразвука. Пациенты были разделены на группы I и II с ΔD≥8% и ΔD<8% соответственно. Группа II была разделена на группы IIA (лерканидипин) и IIB (контроль). Механический тонус изолированных сегментов артерии была первоначально ниже в группе I. Предоперационная терапия лерканидипином (2,5–5 мг/кг в течение 5–7 дней) приводила к значительному увеличению эндотелийзависимой вазодилатации и уменьшению тонуса выделенных сегментов артерии. Предоперационное лечение лерканидипином эффективно сохраняло дилатационные свойства артериального канала.

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