EFFECT OF BISOPROLOL AND ITS COMBINATION WITH INDAPAMIDE ON BLOOD PRESSURE AND CEREBROVASCULAR REACTIVITY IN HYPERTENSIVE PATIENTS WITH RHEUMATOID ARTHRITIS

The aim of the study was to investigate the effects of bisoprolol and its combination with indapamide on blood pressure and cerebrovascular reactivity (CVR) in patients with arterial hypertension (AH) and rheumatoid arthritis (RA). Twenty five patients with AH and RA (age of 56 [53; 67] years; blood pressure (BP) of 145.5 [137; 157]/86 [82; 96] mm Hg) received bisoprolol or its combination with indapamide in a 6‑month open‑controlled study in parallel groups. Ambulatory BP monitoring and evaluation of CVR were performed twice: initially and at the end of the study. CVR was evaluated using transcranial Doppler ultrasound (TCD) of the middle cerebral arteries (MCA) in hyperoxia (HO) and hypercapnia (HC). Bisoprolol and its combination with indapamide decreased significant systolic and diastolic BP (p<0.05–0.01). Bisoprolol therapy did not affect MCA blood flow velocity during HO and HC. Combination therapy (bisoprolol and indapamide) significantly decreased MCA blood flow velocity by 18.1 and 8.3% during hyperoxia at min 1 and 2, respectively (p<0.05). Bisoprolol and its combination with indapamide had a significant antihypertensive effect in patients with AH and RA. Only combination therapy with bisoprolol and indapamide improved CVR in hyperoxia.

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